• Project overview

Definition of relevant HMGB1 targets production
and validation

Screening for primary Affibody molecules

Functional in vitro testing of neutralizing capacities of selected Affibody molecules

Functional validation in vivo in liver toxicity assay

Evaluation of effects in three experimental stroke models

Candidate drug nomination and evaluation

Dissemination of results

WP1 Target production
WP2 Target validation

WP3 Generation and characterization Affibody molecules

WP4 Functional validation in vitro models

WP5 Functional validation in DILI model

WP6 Blood-brain barrier studies
WP7 In vivo stroke models

WP8 CD evaluation

WP9 Management
WP10 Dissemination